Portrait of Margaret van Eyck

Portrait of Margaret van Eyck is a 1439 oil on wood painting by the Early Netherlandish master Jan van Eyck. It is one of the latest of his surviving paintings, and one of the earliest European artworks to depict a painter's spouse. Completed when Margaret van Eyck was around 34, it was hung until the early 18th century in the Bruges chapel of the Guild of painters.

The work is thought to be a pendant or diptych panel for either a now lost self-portrait known from records until 1769, or of Jan van Eyck's likely self-portrait now in the National Gallery in London. It is in the collection of the Groeningemuseum in Bruges, Belgium.